Arizona Cardinals vs San Francisco 49ers
All-time regular-season series · through 2026
Legendary rivalry · 100 intensity86% competitive
51 games played
San Francisco 49ers leads by 7
Win %
43%
57%
Home / Away Split
Arizona Cardinals
Home 12-10Away 10-12
Wins at home: 55%
San Francisco 49ers
Home 16-13Away 13-16
Wins at home: 55%
Recent Meetings
| Season | Location | Result |
|---|---|---|
| 2026 Wk 3 | @ SF | ARI 30–36 SF |
| 2025 Wk 11 | ARI host | ARI 22–41 SF |
| 2025 Wk 3 | @ SF | ARI 15–16 SF |
| 2024 Wk 18 | ARI host | ARI 47–24 SF |
| 2024 Wk 5 | @ SF | ARI 24–23 SF |
Dynasty Context
Arizona Cardinals
- 1974–1976 · 3 seasons · 0🏆 · 74% win
- 2013–2015 · 3 seasons · 0🏆 · 71% win
San Francisco 49ers
- 1983–1998 · 16 seasons · 4🏆 · 75% win
- 2011–2013 · 3 seasons · 0🏆 · 75% win
Simultaneous Dynasty Overlap
2013–2013 (1 seasons): both franchises were in dynasty form. This is an elite-vs-elite period — games in this window carry extra historical weight.
Era Breakdown
Each franchise's overall win% per decade — who was stronger in each era.
| Decade | Arizona Cardinals | vs | San Francisco 49ers | Edge |
|---|---|---|---|---|
| 1970s | 50% | — | 43% | ARI +7pp |
| 1980s | 42% | — | 69% | SF +27pp |
| 1990s | 36% | — | 71% | SF +34pp |
| 2000s | 39% | — | 43% | SF +4pp |
| 2010s | 48% | — | 51% | Even |
| 2020s | 38% | — | 58% | SF +21pp |