64 players · season roster from the StatVault data encyclopedia
| Player | Pos | G | Season Line |
|---|---|---|---|
| Brock Purdy | QB | 7 | 1,748 pass yds · 15 pass TD · 161 rush yds |
| Christian McCaffrey | RB | 7 | 389 rush yds · 8 rush TD · 34 rec |
| George Kittle | TE | 7 | 34 rec · 425 rec yds · 5 rec TD |
| Mike Evans | WR | 6 | 27 rec · 420 rec yds · 3 rec TD |
| Fred Warner | MLB | 7 | 70 tkl · 0.5 sk |
| Deebo Samuel Sr. | WR | 5 | 78 rush yds · 0 rush TD · 16 rec |
| Dre Greenlaw | LB | 6 | 49 tkl · 0 sk |
| Keion White | DE | 5 | 13 tkl · 3.5 sk |
| Kaelon Black | RB | 7 | 233 rush yds · 1 rush TD · 3 rec |
| Ji'Ayir Brown | SAF | 7 | 44 tkl · 0 sk |
| Jaden Dugger | LB | 6 | 30 tkl · 1 sk |
| Marques Sigle | SAF | 4 | 26 tkl · 1 sk |
| Gracen Halton | DT | 5 | 15 tkl · 2 sk |
| Osa Odighizuwa | DT | 7 | 13 tkl · 2 sk |
| Deommodore Lenoir | CB | 7 | 30 tkl · 0 sk |
| Malik Mustapha | SAF | 7 | 28 tkl · 0 sk |
| Jordan Watkins | WR | 3 | 6 rec · 138 rec yds · 0 rec TD |
| Renardo Green | CB | 6 | 26 tkl · 0 sk |
| Romello Height | DE | 5 | 8 tkl · 1.5 sk |
| Upton Stout | CB | 6 | 18 tkl · 0.5 sk |
| Sebastian Valdez | DT | 4 | 8 tkl · 1 sk |
| Mykel Williams | DE | 3 | 7 tkl · 1 sk |
| Demarcus Robinson | WR | 2 | 5 rec · 84 rec yds · 1 rec TD |
| Kyle Juszczyk | FB | 5 | 8 rec · 76 rec yds · 2 rec TD |
| Luke Farrell | TE | 5 | 3 rec · 33 rec yds · 0 rec TD |
| Ogbo Okoronkwo | DE | 3 | 2 tkl · 1 sk |
| Jacob Cowing | WR | 4 | 12 rush yds · 0 rush TD · 4 rec |
| Jack Jones | CB | 5 | 11 tkl · 0 sk |
| Khalid Kareem | DE | 7 | 11 tkl · 0 sk |
| Ashtyn Davis | SAF | 6 | 10 tkl · 0 sk |
| James Thompson Jr. | DT | 4 | 9 tkl · 0 sk |
| KhaDarel Hodge | WR | 3 | 1 rec · 18 rec yds · 0 rec TD |
| Jordan James | RB | 2 | 21 rush yds · 0 rush TD · 1 rec |
| Garret Wallow | LB | 3 | 7 tkl · 0 sk |
| Luke Gifford | LB | 5 | 7 tkl · 0 sk |
| Nick Bosa | DE | 2 | 7 tkl · 0 sk |
| Brandin Cooks | WR | 4 | 3 rec · 33 rec yds · 1 rec TD |
| Brayden Willis | TE | 3 | 6 tkl · 0 sk |
| C.J. West | DT | 2 | 5 tkl · 0 sk |
| Siran Neal | DB | 4 | 5 tkl · 0 sk |
| Jalen Graham | LB | 2 | 4 tkl · 0 sk |
| Naquan Jones | DT | 2 | 2 tkl · 0 sk |
| Colton McKivitz | OT | 1 | 1 tkl · 0 sk |
| Connor Colby | G | 1 | 1 tkl · 0 sk |
| Eddy Pineiro | K | 1 | 1 tkl · 0 sk |
| Kevin Givens | DT | 1 | 1 tkl · 0 sk |
| Matthew Judon | OLB | 1 | 1 tkl · 0 sk |
| Trent Williams | OT | 1 | 1 tkl · 0 sk |
| Jake Brendel | C | 1 | 1 rec · 2 rec yds · 0 rec TD |
| Carver Willis | OT | 7 | — |
| Christian Kirk | WR | 1 | — |
| Corliss Waitman | P | 7 | — |
| De'Zhaun Stribling | WR | 1 | — |
| Dominick Puni | OT | 7 | — |
| Ephesians Prysock | CB | 3 | — |
| Jack Stoll | TE | 1 | — |
| Jake Tonges | TE | 1 | — |
| Jarrett Patterson | C | 7 | — |
| Jon Weeks | LS | 7 | — |
| Malik Turner | WR | 2 | — |
| Tatum Bethune | LB | 2 | — |
| Vederian Lowe | OT | 7 | — |
| Viliami Fehoko Jr. | DE | 1 | — |
| Mac Jones | QB | 1 | -2 rush yds · 0 rush TD |
Solid defense (only 139 points allowed) wasn't enough to overcome the 6-1 record for San Francisco 49ers under Kyle Shanahan.