47 players · season roster from the StatVault data encyclopedia
| Player | Pos | G | Season Line |
|---|---|---|---|
| Brock Purdy | QB | 1 | 205 pass yds · 3 pass TD · 29 rush yds |
| Christian McCaffrey | RB | 1 | 68 rush yds · 0 rush TD · 5 rec |
| Kaelon Black | RB | 1 | 65 rush yds · 0 rush TD · 1 rec |
| Deebo Samuel Sr. | WR | 1 | 12 rush yds · 0 rush TD · 6 rec |
| Fred Warner | MLB | 1 | 11 tkl · 0 sk |
| Demarcus Robinson | WR | 1 | 2 rec · 50 rec yds · 1 rec TD |
| Mike Evans | WR | 1 | 6 rec · 49 rec yds · 1 rec TD |
| Marques Sigle | SAF | 1 | 9 tkl · 0 sk |
| Deommodore Lenoir | CB | 1 | 6 tkl · 0 sk |
| Dre Greenlaw | LB | 1 | 6 tkl · 0 sk |
| Jaden Dugger | LB | 1 | 5 tkl · 0 sk |
| Ji'Ayir Brown | SAF | 1 | 4 tkl · 0 sk |
| Nick Bosa | DE | 1 | 4 tkl · 0 sk |
| Luke Farrell | TE | 1 | 2 rec · 19 rec yds · 0 rec TD |
| George Kittle | TE | 1 | 2 rec · 12 rec yds · 0 rec TD |
| Malik Mustapha | SAF | 1 | 3 tkl · 0 sk |
| Renardo Green | CB | 1 | 3 tkl · 0 sk |
| Ashtyn Davis | SAF | 1 | 2 tkl · 0 sk |
| CJ West | DT | 1 | 2 tkl · 0 sk |
| Garret Wallow | LB | 1 | 2 tkl · 0 sk |
| James Thompson Jr. | DT | 1 | 2 tkl · 0 sk |
| KhaDarel Hodge | WR | 1 | 2 tkl · 0 sk |
| Khalid Kareem | DE | 1 | 2 tkl · 0 sk |
| Osa Odighizuwa | DT | 1 | 2 tkl · 0 sk |
| Upton Stout | CB | 1 | 2 tkl · 0 sk |
| Siran Neal | DB | 1 | 1 tkl · 0 sk |
| Jake Brendel | C | 1 | 1 rec · 2 rec yds · 0 rec TD |
| Carver Willis | OT | 1 | — |
| Colton McKivitz | OT | 1 | — |
| Connor Colby | G | 1 | — |
| Corliss Waitman | P | 1 | — |
| De'Zhaun Stribling | WR | 1 | — |
| Dominick Puni | OT | 1 | — |
| Eddy Pineiro | K | 1 | — |
| Gracen Halton | DT | 1 | — |
| Jack Jones | CB | 1 | 0 tkl · 0 sk |
| Jacob Cowing | WR | 1 | — |
| Jake Tonges | TE | 1 | — |
| Jarrett Patterson | C | 1 | — |
| Jon Weeks | LS | 1 | — |
| Keion White | DE | 1 | — |
| Kyle Juszczyk | FB | 1 | — |
| Luke Gifford | LB | 1 | — |
| Ogbo Okoronkwo | LB | 1 | 0 tkl · 0 sk |
| Romello Height | DE | 1 | — |
| Trent Williams | OT | 1 | — |
| Vederian Lowe | OT | 1 | — |